Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study

The Fuenzalida-Palacios rabies vaccine has been used in South America for rabies post-exposure prophylaxis. To determine the frequency of adverse reactions associated with this vaccine compared to a control group a quasi-experimental study was carried out in Uberlândia, Brazil, from May 1997 to April 1998. Victims of bites or other injuries by dogs or other mammals and who received or not post-exposure prophylaxis with Fuenzalida-Palacios rabies vaccine were compared as to the occurrence of a list of signs and symptoms. Out of 2,440 victims of bites and other injuries from dogs and other mammals 2,114 participated in the study; 1,004 of them provided follow-up information within 10 to 15 days. Headache and pain at the injection sites were the most commonly found symptoms (125/1,000). No neuroparalytic event was detected. Patients who were given Fuenzalida-Palacios rabies vaccine and those who were not had similar incidences of symptoms (risk ratios close to 1). Regarding the occurrence of adverse reactions, Fuenzalida-Palacios rabies vaccine is a valid alternative for rabies post-exposure prophylaxis.

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Main Authors: Bonito,Rosuita Fratari, Oliveira,Neide Mattar de, Nishioka,Sérgio de Andrade
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2004
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000100002
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spelling oai:scielo:S0037-868220040001000022004-03-19Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental studyBonito,Rosuita FratariOliveira,Neide Mattar deNishioka,Sérgio de Andrade Adverse reaction Fuenzalida-Palacios vaccine Post-exposure prophylaxis Quasi-experimental study Rabies vaccine The Fuenzalida-Palacios rabies vaccine has been used in South America for rabies post-exposure prophylaxis. To determine the frequency of adverse reactions associated with this vaccine compared to a control group a quasi-experimental study was carried out in Uberlândia, Brazil, from May 1997 to April 1998. Victims of bites or other injuries by dogs or other mammals and who received or not post-exposure prophylaxis with Fuenzalida-Palacios rabies vaccine were compared as to the occurrence of a list of signs and symptoms. Out of 2,440 victims of bites and other injuries from dogs and other mammals 2,114 participated in the study; 1,004 of them provided follow-up information within 10 to 15 days. Headache and pain at the injection sites were the most commonly found symptoms (125/1,000). No neuroparalytic event was detected. Patients who were given Fuenzalida-Palacios rabies vaccine and those who were not had similar incidences of symptoms (risk ratios close to 1). Regarding the occurrence of adverse reactions, Fuenzalida-Palacios rabies vaccine is a valid alternative for rabies post-exposure prophylaxis.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.37 n.1 20042004-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000100002en10.1590/S0037-86822004000100002
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country Brasil
countrycode BR
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access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Bonito,Rosuita Fratari
Oliveira,Neide Mattar de
Nishioka,Sérgio de Andrade
spellingShingle Bonito,Rosuita Fratari
Oliveira,Neide Mattar de
Nishioka,Sérgio de Andrade
Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study
author_facet Bonito,Rosuita Fratari
Oliveira,Neide Mattar de
Nishioka,Sérgio de Andrade
author_sort Bonito,Rosuita Fratari
title Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study
title_short Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study
title_full Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study
title_fullStr Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study
title_full_unstemmed Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study
title_sort adverse reactions associated with a fuenzalida-palacios rabies vaccine: a quasi-experimental study
description The Fuenzalida-Palacios rabies vaccine has been used in South America for rabies post-exposure prophylaxis. To determine the frequency of adverse reactions associated with this vaccine compared to a control group a quasi-experimental study was carried out in Uberlândia, Brazil, from May 1997 to April 1998. Victims of bites or other injuries by dogs or other mammals and who received or not post-exposure prophylaxis with Fuenzalida-Palacios rabies vaccine were compared as to the occurrence of a list of signs and symptoms. Out of 2,440 victims of bites and other injuries from dogs and other mammals 2,114 participated in the study; 1,004 of them provided follow-up information within 10 to 15 days. Headache and pain at the injection sites were the most commonly found symptoms (125/1,000). No neuroparalytic event was detected. Patients who were given Fuenzalida-Palacios rabies vaccine and those who were not had similar incidences of symptoms (risk ratios close to 1). Regarding the occurrence of adverse reactions, Fuenzalida-Palacios rabies vaccine is a valid alternative for rabies post-exposure prophylaxis.
publisher Sociedade Brasileira de Medicina Tropical - SBMT
publishDate 2004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000100002
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