Phytosterol vehicles used in a functional product modify carotenoid/cholesterol bioaccessibility and uptake by Caco-2 cells
Functional foods containing dispersible phytosterols (DPs) are recommended to reduce cholesterol absorption in humans. However, only a few studies have been conducted on the effect of DP vehicles on carotenoid bioaccessibility and uptake by intestinal cells. On a previously developed fermented maize product containing both DPs and carotenoids, we aim to evaluate the effect of DPs encapsulated by maltodextrin on the carotenoid/phytosterol/cholesterol interactions during gastro-duodenal digestion. Thanks to maltodextrin properties, β-carotene and lycopene bioaccessibilities were significantly improved by 40.2 ± 1.4% while that of β-cryptoxanthin decreased by 14 ± 0.1%. Additionally, the presence of DPs reduced the cholesterol micellarization by 51.8 ± 4.2%. Despite a slight decrease in carotenoid uptake caused by the DP vehicle, related to micelle size, an inhibition of cholesterol accumulation by Caco-2 cells was observed. These results highlighted the key role of maltodextrin as a vehicle of DPs on carotenoid and cholesterol absorption.
| Main Authors: | , , , |
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| Format: | article biblioteca |
| Language: | eng |
| Subjects: | S20 - Physiologie de la nutrition humaine, phytostérol, maltodextrine, absorption digestive, cholestérol, carotène, lycopène, caroténoïde, http://aims.fao.org/aos/agrovoc/c_5847, http://aims.fao.org/aos/agrovoc/c_27570, http://aims.fao.org/aos/agrovoc/c_2272, http://aims.fao.org/aos/agrovoc/c_1584, http://aims.fao.org/aos/agrovoc/c_9632, http://aims.fao.org/aos/agrovoc/c_28451, http://aims.fao.org/aos/agrovoc/c_1333, |
| Online Access: | http://agritrop.cirad.fr/595453/ http://agritrop.cirad.fr/595453/1/595453.pdf |
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