The global distribution and spread of the mobilized colistin resistance gene mcr-1

Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.

Bibliographic Details

Main Authors:	Wang, Ruobing, van Dorp, Lucy, Shaw, Liam P., Bradley, Phelim, Wang, Qi, Wang, Xiaojuan, Jin, Longyang, Zhang, Qing, Liu, Yuqing, Rieux, Adrien, Dorai-Schneiders, Thamarai, Weinert, Lucy Anne, Iqbal, Zamin, Didelot, Xavier, Wang, Hui, Balloux, François
Format:	article biblioteca
Language:	eng
Subjects:	000 - Autres thèmes, Enterobacteriaceae, infection, Résistance aux antibiotiques, colistine, génétique, santé publique, maladie de l'homme, http://aims.fao.org/aos/agrovoc/c_2580, http://aims.fao.org/aos/agrovoc/c_3852, http://aims.fao.org/aos/agrovoc/c_8848, http://aims.fao.org/aos/agrovoc/c_37566, http://aims.fao.org/aos/agrovoc/c_3222, http://aims.fao.org/aos/agrovoc/c_6349, http://aims.fao.org/aos/agrovoc/c_29198,
Online Access:	http://agritrop.cirad.fr/587607/ http://agritrop.cirad.fr/587607/1/s41467-018-03205-z.pdf
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