The global distribution and spread of the mobilized colistin resistance gene mcr-1
Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | article biblioteca |
| Language: | eng |
| Subjects: | 000 - Autres thèmes, Enterobacteriaceae, infection, Résistance aux antibiotiques, colistine, génétique, santé publique, maladie de l'homme, http://aims.fao.org/aos/agrovoc/c_2580, http://aims.fao.org/aos/agrovoc/c_3852, http://aims.fao.org/aos/agrovoc/c_8848, http://aims.fao.org/aos/agrovoc/c_37566, http://aims.fao.org/aos/agrovoc/c_3222, http://aims.fao.org/aos/agrovoc/c_6349, http://aims.fao.org/aos/agrovoc/c_29198, |
| Online Access: | http://agritrop.cirad.fr/587607/ http://agritrop.cirad.fr/587607/1/s41467-018-03205-z.pdf |
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