Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
This article belongs to the Special Issue Editorial Board Members’ Collection Series in “Plant Food Extracts and Phytochemicals”.
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| Format: | artículo biblioteca |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2023
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| Subjects: | Coffee pulp, Cocoa shell, Polyphenols, Caffeine, Glycemia, Adipocytes, |
| Online Access: | http://hdl.handle.net/10261/341728 http://dx.doi.org/10.13039/501100004593 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100011033 |
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dig-cial-es-10261-3417282024-01-06T02:50:17Z Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice Braojos, Cheyenne Gila-Diaz, Andrea Rodríguez-Rodríguez, Pilar Monedero-Cobeta, Ignacio Morales, María Dolores Ruvira, Santiago Ramiro-Cortijo, David Benitez, Vanesa Martín-Cabrejas, María A. Arribas, Silvia M. Universidad Autónoma de Madrid Comunidad de Madrid Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Coffee pulp Cocoa shell Polyphenols Caffeine Glycemia Adipocytes This article belongs to the Special Issue Editorial Board Members’ Collection Series in “Plant Food Extracts and Phytochemicals”. Coffee and cocoa manufacturing produces large amounts of waste. Generated by-products contain bioactive compounds with antioxidant and anti-inflammatory properties, suitable for treating metabolic syndrome (MetS). We aimed to compare the efficacy of aqueous extracts and flours from coffee pulp (CfPulp-E, CfPulp-F) and cocoa shell (CcShell-E, CcShell-F) to ameliorate MetS alterations induced by a high-fat diet (HFD). Bioactive component content was assessed by HPLC/MS. C57BL/6 female mice were fed for 6 weeks with HFD followed by 6 weeks with HFD plus supplementation with one of the ingredients (500 mg/kg/day, 5 days/week), and compared to non-supplemented HFD and Control group fed with regular chow. Body weight, adipocyte size and browning (Mitotracker, confocal microscopy), plasma glycemia (basal, glucose tolerance test–area under the curve, GTT-AUC), lipid profile, and leptin were compared between groups. Cocoa shell ingredients had mainly caffeine, theobromine, protocatechuic acid, and flavan-3-ols. Coffee pulp showed a high content in caffeine, protocatechuic, and chlorogenic acids. Compared to Control mice, HFD group showed alterations in all parameters. Compared to HFD, CcShell-F significantly reduced adipocyte size, increased browning and high-density lipoprotein cholesterol (HDL), and normalized basal glycemia, while CcShell-E only increased HDL. Both coffee pulp ingredients normalized adipocyte size, basal glycemia, and GTT-AUC. Additionally, CfPulp-E improved hyperleptinemia, reduced triglycerides, and slowed weight gain, and CfPulp-F increased HDL. In conclusion, coffee pulp ingredients showed a better efficacy against MetS, likely due to the synergic effect of caffeine, protocatechuic, and chlorogenic acids. Since coffee pulp is already approved as a food ingredient, this by-product could be used in humans to treat obesity-related MetS alterations. This research was funded by the Knowledge Transfer Project from Universidad Autónoma de Madrid (UAM, Madrid, Spain) and AORA Health S.L. (Madrid, Spain), grant number PFTC-19; The Excellence Line (2019–2023) for University Teaching Staff within the Multiannual Agreement between the Community of Madrid (Spain)-UAM; and the Spanish Plan for Scientific, Technical and Innovation Research (2021–2023; PEICTI) within the Spanish Recovery, Transformation and Resilience thought the Projects Oriented to the Ecological Transition and to the Digital Transition (Ministry of Science and Innovation; Spain), grant number TED2021-129262A-I00. Peer reviewed 2024-01-05T11:08:54Z 2024-01-05T11:08:54Z 2023 artículo http://purl.org/coar/resource_type/c_6501 Foods 12(14): 2708 (2023) http://hdl.handle.net/10261/341728 10.3390/foods12142708 2304-8158 http://dx.doi.org/10.13039/501100004593 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100011033 37509800 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI//TED2021-129262A-I00 Publisher's version The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/foods12142708 https://doi.org/10.3390/foods12142708 Sí open application/pdf Multidisciplinary Digital Publishing Institute |
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Coffee pulp Cocoa shell Polyphenols Caffeine Glycemia Adipocytes Coffee pulp Cocoa shell Polyphenols Caffeine Glycemia Adipocytes |
| spellingShingle |
Coffee pulp Cocoa shell Polyphenols Caffeine Glycemia Adipocytes Coffee pulp Cocoa shell Polyphenols Caffeine Glycemia Adipocytes Braojos, Cheyenne Gila-Diaz, Andrea Rodríguez-Rodríguez, Pilar Monedero-Cobeta, Ignacio Morales, María Dolores Ruvira, Santiago Ramiro-Cortijo, David Benitez, Vanesa Martín-Cabrejas, María A. Arribas, Silvia M. Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice |
| description |
This article belongs to the Special Issue Editorial Board Members’ Collection Series in “Plant Food Extracts and Phytochemicals”. |
| author2 |
Universidad Autónoma de Madrid |
| author_facet |
Universidad Autónoma de Madrid Braojos, Cheyenne Gila-Diaz, Andrea Rodríguez-Rodríguez, Pilar Monedero-Cobeta, Ignacio Morales, María Dolores Ruvira, Santiago Ramiro-Cortijo, David Benitez, Vanesa Martín-Cabrejas, María A. Arribas, Silvia M. |
| format |
artículo |
| topic_facet |
Coffee pulp Cocoa shell Polyphenols Caffeine Glycemia Adipocytes |
| author |
Braojos, Cheyenne Gila-Diaz, Andrea Rodríguez-Rodríguez, Pilar Monedero-Cobeta, Ignacio Morales, María Dolores Ruvira, Santiago Ramiro-Cortijo, David Benitez, Vanesa Martín-Cabrejas, María A. Arribas, Silvia M. |
| author_sort |
Braojos, Cheyenne |
| title |
Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice |
| title_short |
Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice |
| title_full |
Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice |
| title_fullStr |
Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice |
| title_full_unstemmed |
Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice |
| title_sort |
effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10261/341728 http://dx.doi.org/10.13039/501100004593 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100011033 |
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