Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
Microalgae represent one of the most promising sources of bioactive compounds for the pharmaceutical and food industries. Among these bioactives, carotenoids could be highlighted due to their health-promoting effects, including anti-inflammatory, neuroprotective or antioxidant properties. In this study, diverse microalgae extracts enriched in carotenoids, including extracts from Haematococcus pluvialis, Nannochloropsis oceanica, Tisochrysis lutea and Porphyridium cruentum, were evaluated through a battery of in vitro neuroprotective assays in an effort to estimate their potential against neurological disorders. Results indicated that microalgae extracts exerted a moderate and selective cholinesterase inhibitory potential, as well as high antioxidant and anti-inflammatory capacities, highlighting N. oceanica and T. lutea extracts. In parallel, cytotoxicity tests and evaluation of the anti-inflammatory capacity of the microalgae extracts were performed using different models. In this regard, N. oceanica extract showed the highest inhibition of pro-inflammatory cytokine release, indicating that this microalga extract could be the most promising neuroprotective agent.
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Elsevier
2022
|
| Subjects: | Alzheimer's disease, Carotenoids, Cytotoxicity, Microalgae, Neuroprotection, Pressurized liquids extraction, |
| Online Access: | http://hdl.handle.net/10261/285054 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|