Peptides in energy balance and obesity
The book focuses on the peptides operating both centrally and peripherally at the same time as providing an integral and integrated perspective of the multifaceted and complex regulation of energy balance homeostasis. Part 1 covers the central pathways involved in the control of food intake (orexigenic neuropeptides that increase or stimulate appetite, and the peptides with anorexigenic effects). Part 2 deals with the peripheral signals participating in energy homeostasis and their control in health and disease. Regulation of body weight was once considered a simple feedback control system in which the hypothalamus modulated food intake and energy expenditure to compensate for fluctuations in body weight. The existing body of evidence has fostered the transition from the classic adipostat, a sensor of body adiposity that informs the hypothalamus about the abundance of energy stores, to a more dynamic and multifactorial model including signals emerging from several different organs such as the gut, the liver, the pancreas and the vascular system. Part 3 describes an integrative approach to current knowledge in energy balance regulation. Specific chapters address the available advances in technology to analyse these complex issues, including functional neuroimaging and the whole range of the 'omics' strategies. The final chapter takes a fresh and innovative look at future potential approaches to obesity management.
| Main Authors: | , |
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| Format: | Texto biblioteca |
| Language: | |
| Published: |
Wallingford (United Kingdom) CABI
2009
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| Subjects: | PEPTIDES, HUMAN NUTRITION, METABOLISM, OVERWEIGHT, PEPTIDE, NUTRITION HUMAINE, METABOLISME, SURPOIDS, PEPTIDOS, NUTRICION HUMANA, METABOLISMO, SOBREPESO, |
| Online Access: | https://www.cabi.org/cabebooks/FullTextPDF/2009/20093157534.pdf |
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| Summary: | The book focuses on the peptides operating both centrally and peripherally at the same time as providing an integral and integrated perspective of the multifaceted and complex regulation of energy balance homeostasis. Part 1 covers the central pathways involved in the control of food intake (orexigenic neuropeptides that increase or stimulate appetite, and the peptides with anorexigenic effects). Part 2 deals with the peripheral signals participating in energy homeostasis and their control in health and disease. Regulation of body weight was once considered a simple feedback control system in which the hypothalamus modulated food intake and energy expenditure to compensate for fluctuations in body weight. The existing body of evidence has fostered the transition from the classic adipostat, a sensor of body adiposity that informs the hypothalamus about the abundance of energy stores, to a more dynamic and multifactorial model including signals emerging from several different organs such as the gut, the liver, the pancreas and the vascular system. Part 3 describes an integrative approach to current knowledge in energy balance regulation. Specific chapters address the available advances in technology to analyse these complex issues, including functional neuroimaging and the whole range of the 'omics' strategies. The final chapter takes a fresh and innovative look at future potential approaches to obesity management. |
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