The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
Abstract: Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the expression of several genes can be modulated by the CFTR activity; among them, SRC, MTND4, CISD1, and IL1B. However, the CFTR signalling mechanism involved in the expression of CFTRdependent genes is unknown. The aim of this work was to determine if intracellular chloride (Cl-Clconcentration, regulating in turn the expression of specific genes
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| Main Authors: | , , , |
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| Format: | Artículo biblioteca |
| Language: | eng eng |
| Published: |
Karger International
2016
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| Subjects: | GENETICA, BIOLOGIA CELULAR, CLORURO INTRACELULAR, FIBROSIS QUISTICA, BIOMEDICINA, SEGUNDO MENSAJERO, BIOLOGIA MOLECULAR, GENES CFTR DEPENDIENTES, |
| Online Access: | https://repositorio.uca.edu.ar/handle/123456789/1454 |
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| Summary: | Abstract: Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the expression of several genes can be modulated by the CFTR activity; among them, SRC, MTND4, CISD1, and IL1B. However, the CFTR signalling mechanism involved in the expression of CFTRdependent genes is unknown. The aim of this work was to determine if intracellular chloride (Cl-Clconcentration, regulating in turn the expression of specific genes |
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