Falls risk, circadian rhythms and melatonin : current perspectives
Abstract: Aging is associated with weakening of the circadian system. The circadian amplitude of most physiological variables is reduced, while the circadian phase becomes more labile and tends to occur earlier with advancing age. As the incidence of falls in older persons could follow circadian variations, a better understanding of conditions in which falls occur can lead to the implementation of countermeasures (such as adjusting the scheduling of hospital staff, or changing the timing of anti-hypertensive medication if falls are related to undesirable circadian patterns of blood pressure and/or heart rate). This includes knowing the times of the day, days of the week, and times of the year when falls are more likely to occur at home or in the hospital. Additionally, the links between aging processes and factors associated with an increased risk of developing autonomic dysfunction are well established. A strong association between heart rate variability indexes and aging has been shown. Circadian rhythms of autonomous nervous system activity may play important role for maintenance of orthostatic tolerance. Whether one is concerned with disease prediction and prevention or maintenance of healthy aging, the study of circadian rhythms and the broader time structure underlying physiopathology is helpful in terms of screening, early diagnosis and prognosis, as well as the timely institution of prophylactic and/or palliative/ curative treatment. Timing the administration of such treatment as a function of circadian (and other) rhythms also could lead to reduction of falls in older persons.
| Main Authors: | , , , , , |
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| Format: | Artículo biblioteca |
| Language: | eng |
| Published: |
Dove Medical Press
2020
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| Subjects: | ENVEJECIMIENTO, RITMO CIRCADIANO, MELATONINA, FISIOLOGIA, RIESGOS, |
| Online Access: | https://repositorio.uca.edu.ar/handle/123456789/11547 |
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| Summary: | Abstract: Aging is associated with weakening of the circadian system. The circadian
amplitude of most physiological variables is reduced, while the circadian phase becomes
more labile and tends to occur earlier with advancing age. As the incidence of falls in older
persons could follow circadian variations, a better understanding of conditions in which falls
occur can lead to the implementation of countermeasures (such as adjusting the scheduling of
hospital staff, or changing the timing of anti-hypertensive medication if falls are related to
undesirable circadian patterns of blood pressure and/or heart rate). This includes knowing the
times of the day, days of the week, and times of the year when falls are more likely to occur
at home or in the hospital. Additionally, the links between aging processes and factors
associated with an increased risk of developing autonomic dysfunction are well established.
A strong association between heart rate variability indexes and aging has been shown.
Circadian rhythms of autonomous nervous system activity may play important role for
maintenance of orthostatic tolerance. Whether one is concerned with disease prediction
and prevention or maintenance of healthy aging, the study of circadian rhythms and the
broader time structure underlying physiopathology is helpful in terms of screening, early
diagnosis and prognosis, as well as the timely institution of prophylactic and/or palliative/
curative treatment. Timing the administration of such treatment as a function of circadian
(and other) rhythms also could lead to reduction of falls in older persons. |
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