The renal effects of a single and intravenous dose of titanium dioxide nanoparticles in adult male rats
Abstract: Most living organisms are exposed to nanomaterials. The renal effects of a single and intravenous dose (5 mg/kg) of titanium dioxide nanoparticles to male adult Wistar rats were obtained analyzing urine samples at 0-5 h, 5-24 h, 24-48 h and 48-72 h, giving as the earliest and significant (p < 0.05) effects: a) increase of the enzymatic activity of γ-glutamiltranspeptidase, and dipeptidylaminopeptidase at all times tested b) increase the concentration of urinary sodium at all times tested c) Increase the concentration of urinary glucose and the urine osmolarity at 5-24 h, 24-48 h, and 48-72 h. Thus, the titanium dioxide nanoparticles produced time-related effects in adult male rats. These renal effects could be used as another biomarker of exposure to nanoparticles.
| Main Authors: | , , , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Asociación Farmacéutica Mexicana A.C.
2015
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-01952015000100047 |
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| Summary: | Abstract: Most living organisms are exposed to nanomaterials. The renal effects of a single and intravenous dose (5 mg/kg) of titanium dioxide nanoparticles to male adult Wistar rats were obtained analyzing urine samples at 0-5 h, 5-24 h, 24-48 h and 48-72 h, giving as the earliest and significant (p < 0.05) effects: a) increase of the enzymatic activity of γ-glutamiltranspeptidase, and dipeptidylaminopeptidase at all times tested b) increase the concentration of urinary sodium at all times tested c) Increase the concentration of urinary glucose and the urine osmolarity at 5-24 h, 24-48 h, and 48-72 h. Thus, the titanium dioxide nanoparticles produced time-related effects in adult male rats. These renal effects could be used as another biomarker of exposure to nanoparticles. |
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