Acquired Hemophilia presenting as Gross hematuria following Kidney Stone – A case report and review of the literature

ABSTRACT A rare condition in itself, acquired hemophilia A, seldom presents as isolated gross hematuria. It is a serious condition with a high mortality rate and thus clinical suspicion followed by prompt diagnosis is imperative (1). In fact, only 8 cases of such presentation of this condition have been reported thus far in the literature. Of these, none describe the initial presentation of hematuria with the inciting event of a kidney stone. We present a case of a 67-year-old man with signs and symptoms of nephrolithiasis accompanied by profuse hematuria, who was subsequently found to have developed expression of factor VIII inhibitor leading to acquired hemophilia A.

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Bibliographic Details
Main Authors: Schmidt-Bowman,Max, Reinstatler,Lael, Raffin,Eric P., Yared,Joseph E., Seigne,John D., Sverrisson,Einar F.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Urologia 2018
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000200390
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Description
Summary:ABSTRACT A rare condition in itself, acquired hemophilia A, seldom presents as isolated gross hematuria. It is a serious condition with a high mortality rate and thus clinical suspicion followed by prompt diagnosis is imperative (1). In fact, only 8 cases of such presentation of this condition have been reported thus far in the literature. Of these, none describe the initial presentation of hematuria with the inciting event of a kidney stone. We present a case of a 67-year-old man with signs and symptoms of nephrolithiasis accompanied by profuse hematuria, who was subsequently found to have developed expression of factor VIII inhibitor leading to acquired hemophilia A.