Analysis of the association between Epstein-Barr virus and classic Hodgkin’s lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization

Analysis of the association between Epstein-Barr virus and classic Hodgkin’s lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization

The prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkin’s lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Sex and age did not differ among patients as to the frequency of CHL. Nodular sclerosis was the predominant histological subtype. LMP1 was found in Reed-Sternberg cells in 67.5% of the cases whereas ISH detected EBER1 in 75.6%. Regarding histological subtypes EBV infection rates were not found statistically different in nodular sclerosis (NS) and mixed cellularity (MC) subtypes (p = 0.66).

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Bibliographic Details
Main Authors: Pinto,Marília Taumaturgo, Ferreira,Francisco Valdeci de Almeida, Pitombeira,Maria da Silva, Magalhães,Silvia Maria Meira, Costa,Clara Maria Bastos Eloy da, Lima Filho,Paulo Wagner Linhares, Férrer,Renata Praciano Correia, Aguiar,Andrei Levine Porfírio de, Rocha Filho,Francisco Dário
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Patologia Clínica 2006
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442006000300009
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Summary:The prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkin’s lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Sex and age did not differ among patients as to the frequency of CHL. Nodular sclerosis was the predominant histological subtype. LMP1 was found in Reed-Sternberg cells in 67.5% of the cases whereas ISH detected EBER1 in 75.6%. Regarding histological subtypes EBV infection rates were not found statistically different in nodular sclerosis (NS) and mixed cellularity (MC) subtypes (p = 0.66).

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