Effect of Stryphnodendron adstringens (barbatimão) bark on animal models of nociception
The antinociceptive activity of the crude extract and fractions of Stryphnodendron adstringens (Martius) Coville (barbatimão) was evaluated. Three experimental models of pain induction were used: abdominal writhing, formalin, and hot plate. The results demonstrated an antinociceptive effect of barbatimão in the experimental models of writhing induced by acetic acid and pain induced by formalin. However, the extracts did not significantly alter latency time on the hot plate in mice. These results suggest that barbatimão extract has a peripheral antinociceptive effect.
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| Main Authors: | , , , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo
2007
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-93322007000300015 |
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| Summary: | The antinociceptive activity of the crude extract and fractions of Stryphnodendron adstringens (Martius) Coville (barbatimão) was evaluated. Three experimental models of pain induction were used: abdominal writhing, formalin, and hot plate. The results demonstrated an antinociceptive effect of barbatimão in the experimental models of writhing induced by acetic acid and pain induced by formalin. However, the extracts did not significantly alter latency time on the hot plate in mice. These results suggest that barbatimão extract has a peripheral antinociceptive effect. |
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