Decellularized Wharton’s Jelly: Biomaterial Potential for Regenerative Medicine Applications - A Mini-Review

Decellularized Wharton’s Jelly: Biomaterial Potential for Regenerative Medicine Applications - A Mini-Review

Abstract The use of Wharton's Jelly (WJ) as a biomaterial is currently undergoing an appearance in the regenerative medicine field. The biomaterials applications focus on the aspects of cellular growth or delivery of proteins capable of stimulating cellular response. However, the basic knowledge about Wharton jelly and decellularization processing technology combined with understanding the physical-chemical properties of this biomaterial is necessary for proper application in regenerative medicine. This mini-review article summarizes information on the composition of WJ, application of drug delivery, in medicine and discusses recent developments with a special focus on its use for regenerative medicine. The most successful and stimulating applications are studies in regenerative medicine and tissue engineering, for wound healing to treat burns, tumor treatment, nanoparticle carriers, and drug delivery systems.

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Bibliographic Details
Main Authors: Gamba,Luize Kremer, Ribeiro,Victoria Stadler Tasca, Simeoni,Rossana Baggio, Gamba,Laiza Kremer, Graf,Elis Cristine Bevian, Denk,Marcos Antônio, Almeida,Meila Bastos de, Simeoni,Paulo Ricardo Baggio, Barbosa,Carlos de Almeida, Francisco,Julio Cesar, Guarita-Souza,Luiz Cesar
Format: Digital revista
Language:English
Published: Instituto de Tecnologia do Paraná - Tecpar 2023
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100303
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Summary:Abstract The use of Wharton's Jelly (WJ) as a biomaterial is currently undergoing an appearance in the regenerative medicine field. The biomaterials applications focus on the aspects of cellular growth or delivery of proteins capable of stimulating cellular response. However, the basic knowledge about Wharton jelly and decellularization processing technology combined with understanding the physical-chemical properties of this biomaterial is necessary for proper application in regenerative medicine. This mini-review article summarizes information on the composition of WJ, application of drug delivery, in medicine and discusses recent developments with a special focus on its use for regenerative medicine. The most successful and stimulating applications are studies in regenerative medicine and tissue engineering, for wound healing to treat burns, tumor treatment, nanoparticle carriers, and drug delivery systems.

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