Effects of transdermal nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients

Effects of transdermal nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients

Introduction and Objective: Pre-eclampsia is a multisystem disorder that complicates 3%-8% of pregnancies in Western countries and constitutes a major source of morbidity and mortality worldwide. The aim of this study was to examine the effects of transdermal nitroglycerin patches on biomarkers of inflammation and vascular lesion in pre-eclamptic patients. Materials and methods: a prospective study was done in 40 nulliparous preeclamptic patients over 25 weeks of gestation who attended the Obstetric Emergency at Hospital Central ‘‘Dr. Urquinaona’’, Maracaibo, Venezuela. Interleukin 6 and 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins (p, E and L) and asymmetric dimethylarginine concentrations were measured before and after nitroglycerin transdermal patches treatment (5 mg/twice a day) for 48 hours. Results: The mean maternal and gestational age was 21.77 ± 3.07 years and 34.23 ± 1.85 weeks respectively. A significant reduction was observed in systolic and diastolic blood pressure after treatment (p<0.05). However, no modifications were observed in Interleukin 6, Interleukin 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins and asymmetric dimethylarginine concentrations. We concluded that treatment with nitroglycerin patches did not produce modifications in serum concentrations of inflammation and vascular lesion biomarkers in preeclamptic patients.

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Bibliographic Details
Main Authors: Reyna-Villasmil,Eduardo, Mejia-Montilla,Jorly, Reyna-Villasmil,Nadia, Torres-Cepeda,Duly, Santos-Bolívar,Joel, Suárez-Torres,Ismael, Wilches-Durán,Sandra, Hernández,Juan Diego, Graterol-Rivas,Modesto, Contreras-Velásquez,Julio, Cerda,Marco, Garicano,Carlos
Format: Digital revista
Language:English
Published: Sociedad Venezolana de Farmacológia y Farmacológia Clínica y Terapéutica. Escuela de Medicina 2016
Online Access:http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0798-02642016000200002
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Summary:Introduction and Objective: Pre-eclampsia is a multisystem disorder that complicates 3%-8% of pregnancies in Western countries and constitutes a major source of morbidity and mortality worldwide. The aim of this study was to examine the effects of transdermal nitroglycerin patches on biomarkers of inflammation and vascular lesion in pre-eclamptic patients. Materials and methods: a prospective study was done in 40 nulliparous preeclamptic patients over 25 weeks of gestation who attended the Obstetric Emergency at Hospital Central ‘‘Dr. Urquinaona’’, Maracaibo, Venezuela. Interleukin 6 and 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins (p, E and L) and asymmetric dimethylarginine concentrations were measured before and after nitroglycerin transdermal patches treatment (5 mg/twice a day) for 48 hours. Results: The mean maternal and gestational age was 21.77 ± 3.07 years and 34.23 ± 1.85 weeks respectively. A significant reduction was observed in systolic and diastolic blood pressure after treatment (p<0.05). However, no modifications were observed in Interleukin 6, Interleukin 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins and asymmetric dimethylarginine concentrations. We concluded that treatment with nitroglycerin patches did not produce modifications in serum concentrations of inflammation and vascular lesion biomarkers in preeclamptic patients.

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