Recommendations of the Brazilian Society of Rheumatology for the diagnosis and treatment of chikungunya fever. Part 2 - Treatment

Recommendations of the Brazilian Society of Rheumatology for the diagnosis and treatment of chikungunya fever. Part 2 - Treatment

Abstract Chikungunya fever has become an important public health problem in countries where epidemics occur because half of the cases progress to chronic, persistent and debilitating arthritis. Literature data on specific therapies at the various phases of arthropathy caused by chikungunya virus (CHIKV) infection are limited, lacking quality randomized trials assessing the efficacies of different therapies. There are a few studies on the treatment of musculoskeletal manifestations of chikungunya fever, but these studies have important methodological limitations. The data currently available preclude conclusions favorable or contrary to specific therapies, or an adequate comparison between the different drugs used. The objective of this study was to develop recommendations for the treatment of chikungunya fever in Brazil. A literature review was performed via evidence-based selection of articles in the databases Medline, SciELO, PubMed and Embase and conference proceedings abstracts, in addition to expert opinions to support decision-making in defining recommendations. The Delphi method was used to define the degrees of agreement in 2 face-to-face meetings and several online voting rounds. This study is part 2 of the Recommendations of the Brazilian Society of Rheumatology (Sociedade Brasileira de Reumatologia - SBR) for the Diagnosis and Treatment of chikungunya fever and specifically addresses treatment.

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Main Authors: Marques,Claudia Diniz Lopes, Duarte,Angela Luzia Branco Pinto, Ranzolin,Aline, Dantas,Andrea Tavares, Cavalcanti,Nara Gualberto, Gonçalves,Rafaela Silva Guimarães, Rocha Junior,Laurindo Ferreira da, Valadares,Lilian David de Azevedo, Melo,Ana Karla Guedes de, Freire,Eutilia Andrade Medeiros, Teixeira,Roberto, Neto,Francisco Alves Bezerra, Medeiros,Marta Maria das Chagas, Carvalho,Jozélio Freire de, Santos,Mario Sergio F., Océa,Regina Adalva de L. Couto, Levy,Roger A., Andrade,Carlos Augusto Ferreira de, Pinheiro,Geraldo da Rocha Castelar, Abreu,Mirhelen Mendes, Verztman,José Fernando, Merenlender,Selma, Ribeiro,Sandra Lucia Euzebio, Costa,Izaias Pereira da, Pileggi,Gecilmara, Trevisani,Virginia Fernandes Moça, Lopes,Max Igor Banks, Brito,Carlos, Figueiredo,Eduardo, Queiroga,Fabio, Feitosa,Tiago, Tenório,Angélica da Silva, Siqueira,Gisela Rocha de, Paiva,Renata, Vasconcelos,José Tupinambá Sousa, Christopoulos,Georges
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Reumatologia 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000800004
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Summary:Abstract Chikungunya fever has become an important public health problem in countries where epidemics occur because half of the cases progress to chronic, persistent and debilitating arthritis. Literature data on specific therapies at the various phases of arthropathy caused by chikungunya virus (CHIKV) infection are limited, lacking quality randomized trials assessing the efficacies of different therapies. There are a few studies on the treatment of musculoskeletal manifestations of chikungunya fever, but these studies have important methodological limitations. The data currently available preclude conclusions favorable or contrary to specific therapies, or an adequate comparison between the different drugs used. The objective of this study was to develop recommendations for the treatment of chikungunya fever in Brazil. A literature review was performed via evidence-based selection of articles in the databases Medline, SciELO, PubMed and Embase and conference proceedings abstracts, in addition to expert opinions to support decision-making in defining recommendations. The Delphi method was used to define the degrees of agreement in 2 face-to-face meetings and several online voting rounds. This study is part 2 of the Recommendations of the Brazilian Society of Rheumatology (Sociedade Brasileira de Reumatologia - SBR) for the Diagnosis and Treatment of chikungunya fever and specifically addresses treatment.

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