Characterization and cardiovascular effects of (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone, a diterpenoid isolated from Leonotis leonurus
A new diterpenoid, (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone (1), was isolated from Leonotis leonurus and the structure determined via NMR analysis. The compound causes significant changes in blood pressure of anaesthetized normotensive rats and exhibits a negative chronotropic effect.
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| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
The South African Chemical Institute
2008
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| Online Access: | http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0379-43502008000100027 |
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| Summary: | A new diterpenoid, (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone (1), was isolated from Leonotis leonurus and the structure determined via NMR analysis. The compound causes significant changes in blood pressure of anaesthetized normotensive rats and exhibits a negative chronotropic effect. |
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