Layered cryogels laden with Brazilian honey intended for wound care

Layered cryogels laden with Brazilian honey intended for wound care

Abstract PVA cryogels are well established as candidate biomaterials for wound healing applications but are not themselves biodegradable or antimicrobial. Blending PVA with NaCMC (CMC) or gelatin (G) can increase the gel’s ability to swell and would introduce a degree of biodegradability. The incorporation of appropriate amounts of a natural antimicrobial/healing agents, such as honey (H), would contribute to the gels properties. The present work addresses the development and characterization of layered gels (PVA-H, PVA-CMC-H and PVA-G-H, with empty PVA, PVA-CMC, PVA-G gels presented as controls). The gels were characterized by FTIR, DSC, in vitro analysis of swelling and microbiological (S. aureus) effects. Addition of gelatin, NaCMC and honey to PVA diminished the PVA chains’ ability to pack into crystallites. Samples containing honey swelled less and presented higher weight loss/biodegradability than samples without honey. Only the honey-laden PVA-CMC and PVA-G presented activity against S. aureus.

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Bibliographic Details
Main Authors: Santos,Gabriela de Souza dos, Santos,Natália Rodrigues Rojas dos, Pereira,Ingrid Cristina Soares, Andrade Júnior,Antonio José de, Lima,Edla Maria Bezerra, Minguita,Adriana Paula, Rosado,Luiz Henrique Guerreiro, Moreira,Ana Paula Duarte, Middea,Antonieta, Prudencio,Edlene Ribeiro, Luchese,Rosa Helena, Oliveira,Renata Nunes
Format: Digital revista
Language:English
Published: Associação Brasileira de Polímeros 2020
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300407
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Summary:Abstract PVA cryogels are well established as candidate biomaterials for wound healing applications but are not themselves biodegradable or antimicrobial. Blending PVA with NaCMC (CMC) or gelatin (G) can increase the gel’s ability to swell and would introduce a degree of biodegradability. The incorporation of appropriate amounts of a natural antimicrobial/healing agents, such as honey (H), would contribute to the gels properties. The present work addresses the development and characterization of layered gels (PVA-H, PVA-CMC-H and PVA-G-H, with empty PVA, PVA-CMC, PVA-G gels presented as controls). The gels were characterized by FTIR, DSC, in vitro analysis of swelling and microbiological (S. aureus) effects. Addition of gelatin, NaCMC and honey to PVA diminished the PVA chains’ ability to pack into crystallites. Samples containing honey swelled less and presented higher weight loss/biodegradability than samples without honey. Only the honey-laden PVA-CMC and PVA-G presented activity against S. aureus.

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