High volume online post-dilution hemodiafiltration: how relevant is it in chronic kidney disease?

ABSTRACT Online hemodiafiltration is potentially a superior mode of dialysis compared to conventional hemodialysis. However, prospective randomized controlled trials have failed to demonstrate such superiority. Post-hoc analyses of these trials have indicated that high volume post-dilution hemodiafiltration is associated with lower death rates than conventional dialysis. This study discusses whether the lower death rates ascribed to high volume hemodiafiltration are linked to convection volume or the time on dialysis needed to achieve high convection volumes.

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Bibliographic Details
Main Author: Castro,Manuel Carlos Martins
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Nefrologia 2022
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022000200238
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Summary:ABSTRACT Online hemodiafiltration is potentially a superior mode of dialysis compared to conventional hemodialysis. However, prospective randomized controlled trials have failed to demonstrate such superiority. Post-hoc analyses of these trials have indicated that high volume post-dilution hemodiafiltration is associated with lower death rates than conventional dialysis. This study discusses whether the lower death rates ascribed to high volume hemodiafiltration are linked to convection volume or the time on dialysis needed to achieve high convection volumes.