A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum

A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum

Phytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.

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Main Authors: Pereira,Laiane Caline Oliveira, Abreu,Lucas Silva, Silveira,Mayra Bitencourt, Nascimento,Yuri Mangueira do, Souza,Thalisson Amorim de, Hyaric,Mireille Le, Lisboa,Thaís Mangeon Honorato, Sobral,Marianna Vieira, Velozo,Eudes da Silva, Tavares,Josean Fechine, Silva,Marcelo Sobral da
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2020
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500568
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spelling oai:scielo:S0100-404220200005005682020-06-25A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianumPereira,Laiane Caline OliveiraAbreu,Lucas SilvaSilveira,Mayra BitencourtNascimento,Yuri Mangueira doSouza,Thalisson Amorim deHyaric,Mireille LeLisboa,Thaís Mangeon HonoratoSobral,Marianna VieiraVelozo,Eudes da SilvaTavares,Josean FechineSilva,Marcelo Sobral da A-seco-limonoid alkaloid Dictyoloma vandellianum Rutaceae cytotoxicity Phytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.43 n.5 20202020-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500568en10.21577/0100-4042.20170515
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Pereira,Laiane Caline Oliveira
Abreu,Lucas Silva
Silveira,Mayra Bitencourt
Nascimento,Yuri Mangueira do
Souza,Thalisson Amorim de
Hyaric,Mireille Le
Lisboa,Thaís Mangeon Honorato
Sobral,Marianna Vieira
Velozo,Eudes da Silva
Tavares,Josean Fechine
Silva,Marcelo Sobral da
spellingShingle Pereira,Laiane Caline Oliveira
Abreu,Lucas Silva
Silveira,Mayra Bitencourt
Nascimento,Yuri Mangueira do
Souza,Thalisson Amorim de
Hyaric,Mireille Le
Lisboa,Thaís Mangeon Honorato
Sobral,Marianna Vieira
Velozo,Eudes da Silva
Tavares,Josean Fechine
Silva,Marcelo Sobral da
A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
author_facet Pereira,Laiane Caline Oliveira
Abreu,Lucas Silva
Silveira,Mayra Bitencourt
Nascimento,Yuri Mangueira do
Souza,Thalisson Amorim de
Hyaric,Mireille Le
Lisboa,Thaís Mangeon Honorato
Sobral,Marianna Vieira
Velozo,Eudes da Silva
Tavares,Josean Fechine
Silva,Marcelo Sobral da
author_sort Pereira,Laiane Caline Oliveira
title A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_short A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_full A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_fullStr A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_full_unstemmed A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_sort new seco-limonoid from the inflorescences of dictyoloma vandellianum
description Phytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.
publisher Sociedade Brasileira de Química
publishDate 2020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500568
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