A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum

A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum

Phytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.

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Bibliographic Details
Main Authors: Pereira,Laiane Caline Oliveira, Abreu,Lucas Silva, Silveira,Mayra Bitencourt, Nascimento,Yuri Mangueira do, Souza,Thalisson Amorim de, Hyaric,Mireille Le, Lisboa,Thaís Mangeon Honorato, Sobral,Marianna Vieira, Velozo,Eudes da Silva, Tavares,Josean Fechine, Silva,Marcelo Sobral da
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2020
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500568
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Summary:Phytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.

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