Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil

Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil

The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.

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Bibliographic Details
Main Authors: Marx,Camila, Gregianini,Tatiana Schaffer, Lehmann,Fernanda Kieling Moreira, Lunge,Vagner Ricardo, Carli,Silvia de, Dambros,Bibiana Paula, Tumioto,Gabriela Luchiari, Seadi,Claudete, Fonseca,Andre Salvador Kazantzi, Ikuta,Nilo
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2013
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000300392
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Summary:The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.

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