Prevalence of HLA DQB1*0602 allele in patients with migraine

BACKGROUND: Studies have shown a high prevalence of migraine among narcoleptic patients. HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy. An increase in the HLA-DRB1 allele frequency in patients with visual aura has raised greater awareness of the genetic background in migraine. PURPOSE: Since the regions DR and DQ of the HLA are in tightly linkage desiquilibrium we hypothesize that HLA-DQB1*0602 might be associated to the pathophysiology of migraine. METHOD: We analyzed the presence of HLA DQB1*0602 allele in 50 healthy subjects with no history of migraine, 53 patients with migraine without aura and 52 patients with migraine with aura. RESULTS: There was no difference in the frequency of HLA DQB1*0602 allele when control subjects and all patients were compared. We failed to note any difference in frequencies when comparing migraine patients with and without aura. CONCLUSION: Further studies with different patient populations, with other hypothalamic markers (melatonin, hypocretin) in migraine patients may shed light on to its pathophysiology.

Bibliographic Details

Main Authors:	Coelho,Fernando Morgadinho Santos, Pradella-Hallinan,Márcia, Abud,Paulo Corrêa, Predazzoli Neto,Mario, Moreira,Fabio, Bittencourt,Lia Rita Azeredo, Peres,Mario Fernandes Pietro, Tufik,Sérgio
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 2007
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000700005
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