Studies on thyroid and hypophysary thyrotrophic hormone (TSH) in Down syndrome
Serum TSH was studied in 22 patients with Down syndrome, from 4 to 15 years old. In 6 of these patients radioiodine uptake by thyroid gland after 2 and 24 hours of administration and clearance rates before and after TSH stimulus (10 µl-IM) were measured. Results show that serum TSH was normal in 17 patients and above normal limits in 5 patients. Thyroid uptake after 2 hours as well clearance rates, both below normal, had a response to TSH stimulus with normal or below values. These data along with previous reports, suggest, that in children with Down syndrome, there is a thyroid dysfunction in which a slow response no TSH stimulus seems to be the basic defect.
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| Main Authors: | , , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia - ABNEURO
1977
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1977000100001 |
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| Summary: | Serum TSH was studied in 22 patients with Down syndrome, from 4 to 15 years old. In 6 of these patients radioiodine uptake by thyroid gland after 2 and 24 hours of administration and clearance rates before and after TSH stimulus (10 µl-IM) were measured. Results show that serum TSH was normal in 17 patients and above normal limits in 5 patients. Thyroid uptake after 2 hours as well clearance rates, both below normal, had a response to TSH stimulus with normal or below values. These data along with previous reports, suggest, that in children with Down syndrome, there is a thyroid dysfunction in which a slow response no TSH stimulus seems to be the basic defect. |
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