Predictive factors of early graft loss in living donor liver transplantation

Predictive factors of early graft loss in living donor liver transplantation

CONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. The GRBW ratio was categorized into < 0.8 and MELD score into &gt;18. The chi-square test, Student t-test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. RESULTS: MELD score <18 (P<0.001) and serum sodium level &gt; 135 mEq/L (P = 0.03) were higher in group II than in group I. In the multivariate analysis MELD scores &gt; 18 (P<0.001) and GRBW ratios < 0.8 (P<0.04) were significant. CONCLUSIONS: MELD scores &gt;18 and GRBW < 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation.

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Bibliographic Details
Main Authors: Alves,Rogério Camargo Pinheiro, Fonseca,Eduardo Antunes da, Mattos,Carla Adriana Loureiro de, Abdalla,Sofia, Gonçalves,José Eduardo, Waisberg,Jaques
Format: Digital revista
Language:English
Published: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000200011
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Summary:CONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. The GRBW ratio was categorized into < 0.8 and MELD score into &gt;18. The chi-square test, Student t-test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. RESULTS: MELD score <18 (P<0.001) and serum sodium level &gt; 135 mEq/L (P = 0.03) were higher in group II than in group I. In the multivariate analysis MELD scores &gt; 18 (P<0.001) and GRBW ratios < 0.8 (P<0.04) were significant. CONCLUSIONS: MELD scores &gt;18 and GRBW < 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation.

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