Experimental intraoperative use of perfluorotributylamine, perfluorodecaline, and perfluoropolyether
ABSTRACT The perfluorocarbon liquids (PFCLs) are a group of compounds with a specific gravity greater than water that are used as an adjunct in the surgical management of complicated vitreoretinal diseases. Thirty-two pigmented rabbits underwent vitrectomy with injection of one of three PFCLs or saline into the vitreous cavity: eight eyes received perfluorotributylamine (PFTA); eight eyes received perfluorodecaline (PFDC); eight eyes received perfluoropolyether (PFPE); the remaining eight eyes, which served as controls, received saline. One hour after placement in the eyes the PFCLs were removed from the vitreous cavity and the eyes were filled with saline. The rabbits were then euthanized and the eyes enucleated and processed for histologic examination. Light microscopy demonstrated no significant difference between eyes with the PfCLs compared with those of control animais. Electron microscopy revealed only minor changes, consisting of a few irregulary shaped defects in the outer segment discs of photoreceptors, in the PFDC group only. These findings suggest that short-term intraoperative use of PFTA, PFPE, and PFDC, at least in this experimental animal model, is not associated with any significant retinal pathology.
| Main Authors: | , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Conselho Brasileiro de Oftalmologia
1992
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27491992000300112 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | ABSTRACT The perfluorocarbon liquids (PFCLs) are a group of compounds with a specific gravity greater than water that are used as an adjunct in the surgical management of complicated vitreoretinal diseases. Thirty-two pigmented rabbits underwent vitrectomy with injection of one of three PFCLs or saline into the vitreous cavity: eight eyes received perfluorotributylamine (PFTA); eight eyes received perfluorodecaline (PFDC); eight eyes received perfluoropolyether (PFPE); the remaining eight eyes, which served as controls, received saline. One hour after placement in the eyes the PFCLs were removed from the vitreous cavity and the eyes were filled with saline. The rabbits were then euthanized and the eyes enucleated and processed for histologic examination. Light microscopy demonstrated no significant difference between eyes with the PfCLs compared with those of control animais. Electron microscopy revealed only minor changes, consisting of a few irregulary shaped defects in the outer segment discs of photoreceptors, in the PFDC group only. These findings suggest that short-term intraoperative use of PFTA, PFPE, and PFDC, at least in this experimental animal model, is not associated with any significant retinal pathology. |
|---|