HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS)

HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS)

OBJECTIVE: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. METHODS: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. RESULTS: In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p < 0.001). The cut-off values for IR were: HOMA1-IR &gt; 2.7 and HOMA2-IR &gt; 1.8; and, for MS were: HOMA1-IR &gt; 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR &gt; 1.4 (sensitivity: 79.2%; specificity: 61.2%). CONCLUSION: The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations.

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Bibliographic Details
Main Authors: Geloneze,Bruno, Vasques,Ana Carolina Junqueira, Stabe,Christiane França Camargo, Pareja,José Carlos, Rosado,Lina Enriqueta Frandsen Paez de Lima, Queiroz,Elaine Cristina de, Tambascia,Marcos Antonio
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Endocrinologia e Metabologia 2009
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200020
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Summary:OBJECTIVE: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. METHODS: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. RESULTS: In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p < 0.001). The cut-off values for IR were: HOMA1-IR &gt; 2.7 and HOMA2-IR &gt; 1.8; and, for MS were: HOMA1-IR &gt; 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR &gt; 1.4 (sensitivity: 79.2%; specificity: 61.2%). CONCLUSION: The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations.

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