In silico analysis of miRNA target genes possibly induced by tuberculosis infection
The objective was to identify, through in silico analysis, the genes to which miR-146a, miR-146b, and miR-155 bind and to analyze the metabolic pathways in which they participate during tuberculosis infection. For the analysis, it was used: miRBase, UniProtKB, TargetScan Human, miRDB, and miRTarBase. miR-146a interacts with or binds to genes important in cell adhesion and the process of phagocytosis (CLDN16 and ATP6V1C2, respectively) (P< 0.05); this interaction could have important implications in the pathogenesis of tuberculosis or related diseases. The results of this work suggest that the activation of specific molecular mechanisms in response to tuberculosis is regulated by miR-146a, miR-146b, and miR-155. The genes with which miR-146a and miR-155 interact or bind are involved in the immune response and cellular processes essential during tuberculosis infection.
| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | spa eng |
| Published: |
Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias
2024
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| Online Access: | https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/6463 |
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| Summary: | The objective was to identify, through in silico analysis, the genes to which miR-146a, miR-146b, and miR-155 bind and to analyze the metabolic pathways in which they participate during tuberculosis infection. For the analysis, it was used: miRBase, UniProtKB, TargetScan Human, miRDB, and miRTarBase. miR-146a interacts with or binds to genes important in cell adhesion and the process of phagocytosis (CLDN16 and ATP6V1C2, respectively) (P< 0.05); this interaction could have important implications in the pathogenesis of tuberculosis or related diseases. The results of this work suggest that the activation of specific molecular mechanisms in response to tuberculosis is regulated by miR-146a, miR-146b, and miR-155. The genes with which miR-146a and miR-155 interact or bind are involved in the immune response and cellular processes essential during tuberculosis infection. |
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