Hematocrit and hemoglobin levels at adulthood are determined by neonatal hypoxic exposure in rats living at high altitude
Introduction: In previous work performed at sea level we reported that exposure to neonatal hypoxia impairs ventilatory and hematological responses to chronic hypoxia later in life. These findings supported the hypothesis that neonatal hypoxia might be a critical factor in the development of chronic mountain sickness, which mainly occurs in men at high altitude, and is characterized by hypoventilation and excessive erythocytosis. In the present work we tested the hypothesis that hypoxia during early life has long-lasting impacts on the hematological acclimation in adult rats permanently living at high altitude...
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| Main Authors: | , , , , |
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| Format: | Article biblioteca |
| Language: | English |
| Published: |
High Altitude Medicine & Biology
2010-08-08
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| Subjects: | HEMATOCRITO Y HEMOGLOBINA, HIPOXIA NEONATAL, RATAS, ALTURA, |
| Online Access: | http://repositorio.umsa.bo/xmlui/handle/123456789/8113 |
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| Summary: | Introduction: In previous work performed at sea level we
reported that exposure to neonatal hypoxia impairs ventilatory and hematological responses to chronic hypoxia later in
life. These findings supported the hypothesis that neonatal
hypoxia might be a critical factor in the development of
chronic mountain sickness, which mainly occurs in men at
high altitude, and is characterized by hypoventilation and
excessive erythocytosis. In the present work we tested the
hypothesis that hypoxia during early life has long-lasting
impacts on the hematological acclimation in adult rats permanently living at high altitude... |
|---|