A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n = 2,420) or cord blood (n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value

Bibliographic Details

Main Authors:	Monasso, Giulietta S., Hoang, Thanh T., Mancano, Giulia, Fernández-Barrés, Sílvia, Dou, John, Jaddoe, Vincent W.V., Page, Christian M., Johnson, Laura, Bustamante, Mariona, Bakulski, Kelly M., Håberg, Siri E., Ueland, Per M., Battram, Thomas, Merid, Simon K., Melén, Erik, Caramaschi, Doretta, Küpers, Leanne K., Sunyer, Jordi, Nystad, Wenche, Heil, Sandra G., Schmidt, Rebecca J., Vrijheid, Martine, Sharp, Gemma C., London, Stephanie J., Felix, Janine F.
Format:	Dataset biblioteca
Published:	Taylor & Francis
Subjects:	DNA methylation, PACE consortium, Vitamin B12, cohort study, epidemiology, meta-analysis,
Online Access:	https://research.wur.nl/en/datasets/a-meta-analysis-of-epigenome-wide-association-studies-on-pregnanc
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