Effect of a TLR1A polymorphism on natural antibodies in poultry
The aim of the current study was to confirm and characterise the effect of a polymorphism in the Toll-like receptor 1 family member A (TLR1A) gene on levels of natural antibodies (NAb) in poultry. The study population consisted of a base population and 7 generations of birds from a High and Low selection line. Genotypes for a polymorphism in TLR1A were available for chickens in generations 5, 6 and 7. The TLR1A polymorphism had large and significant effects on total NAb levels (IgTotal) and IgM NAb, with full dominance of the TLR1A C allele. Significant (TLR1A*Generation) interactions were detected for IgM and IgTotal. The frequency of the TLR1A C allele was 0.45 in the base population (based on imputed genotypes), 0.66 and 0.04 in generation 7 of the High and Low line, respectively. Results confirm the major effect of this polymorphism in TLR1A on NAb levels suggest high sensitivity of the effect to environmental factors.
| Main Authors: | , , , , , , |
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| Format: | Article in monograph or in proceedings biblioteca |
| Language: | English |
| Published: |
Wageningen Academic Publishers
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| Subjects: | Life Science, |
| Online Access: | https://research.wur.nl/en/publications/effect-of-a-tlr1a-polymorphism-on-natural-antibodies-in-poultry |
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| Summary: | The aim of the current study was to confirm and characterise the effect of a polymorphism in the Toll-like receptor 1 family member A (TLR1A) gene on levels of natural antibodies (NAb) in poultry. The study population consisted of a base population and 7 generations of birds from a High and Low selection line. Genotypes for a polymorphism in TLR1A were available for chickens in generations 5, 6 and 7. The TLR1A polymorphism had large and significant effects on total NAb levels (IgTotal) and IgM NAb, with full dominance of the TLR1A C allele. Significant (TLR1A*Generation) interactions were detected for IgM and IgTotal. The frequency of the TLR1A C allele was 0.45 in the base population (based on imputed genotypes), 0.66 and 0.04 in generation 7 of the High and Low line, respectively. Results confirm the major effect of this polymorphism in TLR1A on NAb levels suggest high sensitivity of the effect to environmental factors. |
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