Sub-chronic toxicity study in rats orally exposed to nanostructured silica

Sub-chronic toxicity study in rats orally exposed to nanostructured silica

Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.

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Bibliographic Details
Main Authors: van der Zande, M., Vandebriel, R.J., Groot, M.J., Kramer, E.H.M., Herrera Riviera, Z.E., Rasmussen, K., Ossenkoppele, J.S., Tromp, P., Gremmer, E.R., Peters, R.J.B., Hendriksen, P.J., Marvin, H.J.P., Hoogenboom, L.A.P., Peijnenburg, A.A.C.M., Bouwmeester, H.
Format: Article/Letter to editor biblioteca
Language:English
Subjects:absorption, acid, elimination, expression profiles, foods, in-vivo biodistribution, injection, liver fibrosis, nanoparticles, size,
Online Access:https://research.wur.nl/en/publications/sub-chronic-toxicity-study-in-rats-orally-exposed-to-nanostructur
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Summary:Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.

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