Short communication: Genome-wide scan for bovine milk-fat composition. II. Quantitative trait loci for long-chain fatty acids

We present the results of a genome-wide scan to identify quantitative trait loci (QTL) that contribute to genetic variation in long-chain milk fatty acids. Milk-fat composition phenotypes were available on 1,905 Dutch Holstein-Friesian cows. A total of 849 cows and their 7 sires were genotyped for 1,341 single nucleotide polymorphisms across all Bos taurus autosomes (BTA). We detected significant QTL on BTA14, BTA15, and BTA16: for C18:1 cis-9, C18:1 cis-12, C18:2 cis-9,12, CLA cis-9,trans-11, C18:3 cis-9,12,15, the C18 index, the total index, total saturated fatty acids, total unsaturated fatty acids (UFA), and the ratio of saturated fatty acids:unsaturated fatty acids on BTA14; for C18:1 trans fatty acids on BTA15; and for the C18 and CLA indices on BTA16. The QTL explained 3 to 19% of the phenotypic variance. Suggestive QTL were found on 16 other chromosomes. The diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism on BTA14, which is known to influence fatty acid composition, most likely explains the QTL that was detected on BTA14

Bibliographic Details

Main Authors:	Schennink, A., Stoop, W.M., Visker, M.H.P.W., van der Poel, J.J., Bovenhuis, H., van Arendonk, J.A.M.
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	cows, dairy-cattle, dgat1, f-2 population, fish-oil, genetic-parameters, polymorphism, qtl, rat-liver, trans,
Online Access:	https://research.wur.nl/en/publications/short-communication-genome-wide-scan-for-bovine-milk-fat-composit
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