ABC transporters from Botrytis cinerea in biotic and abiotic interactions
Botrytis cinereais the causal agent of grey mould disease on a wide variety of crop plants. It is relatively insensitive to natural and synthetic fungitoxic compounds. This thesis describes how ABC (ATP-binding cassette) transporters contribute to protection by actively secreting toxicants from fungal cells, acting as a firsts aid kit. The expression of twelve ABC transporters and three MFS transporters are differentially induced by plant defence compounds, antibiotics and fungicides. BcatrD can decrease sensitivity to azole fungicides, whereas BcatrB is a true multidrug transporter and can provide protection against the plant defence compounds resveratrol and eugenol, phenylpyrrole fungicides and phenazines antibiotics. By exporting resveratrol BcatrB contributes to virulence ofB. cinereaon grapevine. With their ability to protect against fungicides the ABC transporters BcatrB and BcatrD can contribute to the apparent ease by whichB. cinereadevelops resistance against fungicides. The protection against antibiotics is a clear advantage in competition with other microorganisms.
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| Format: | Doctoral thesis biblioteca |
| Language: | English |
| Subjects: | active transport, botrytis cinerea, eugenol, gene expression, genes, host parasite relationships, pathogenesis-related proteins, plant pathogenic fungi, actief transport, gastheer parasiet relaties, genen, genexpressie, pathogenesis-gerelateerde eiwitten, plantenziekteverwekkende schimmels, |
| Online Access: | https://research.wur.nl/en/publications/abc-transporters-from-botrytis-cinerea-in-biotic-and-abiotic-inte |
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| Summary: | Botrytis cinereais the causal agent of grey mould disease on a wide variety of crop plants. It is relatively insensitive to natural and synthetic fungitoxic compounds. This thesis describes how ABC (ATP-binding cassette) transporters contribute to protection by actively secreting toxicants from fungal cells, acting as a firsts aid kit. The expression of twelve ABC transporters and three MFS transporters are differentially induced by plant defence compounds, antibiotics and fungicides. BcatrD can decrease sensitivity to azole fungicides, whereas BcatrB is a true multidrug transporter and can provide protection against the plant defence compounds resveratrol and eugenol, phenylpyrrole fungicides and phenazines antibiotics. By exporting resveratrol BcatrB contributes to virulence ofB. cinereaon grapevine. With their ability to protect against fungicides the ABC transporters BcatrB and BcatrD can contribute to the apparent ease by whichB. cinereadevelops resistance against fungicides. The protection against antibiotics is a clear advantage in competition with other microorganisms. |
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