A new approach to functionalized cyclobutanes: Stereoselective synthesis of the enantiomers of grandisol and fraganol
Enantiomerically enriched (+)-grandisol and (+)-fraganol were synthesized using as the key step a new stereoselective synthesis of cyclobutanes fused to γ-lactones by a stereochemically-controlled intramolecular alkylation of α-benzenesulfonyl-γ-lactones. This method provides a way to synthesize the enantiomers in a straightforward manner.
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Elsevier
1995-05
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| Subjects: | Functionalized cyclobutanes, Synthesis of the enantiomers, Grandisol, Fraganol, |
| Online Access: | http://hdl.handle.net/10261/211879 http://dx.doi.org/10.13039/501100008737 |
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| Summary: | Enantiomerically enriched (+)-grandisol and (+)-fraganol were synthesized using as the key step a new stereoselective synthesis of cyclobutanes fused to γ-lactones by a stereochemically-controlled intramolecular alkylation of α-benzenesulfonyl-γ-lactones. This method provides a way to synthesize the enantiomers in a straightforward manner. |
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