Cytotoxic sesquiterpene lactones and other constituents of centaurea omphalotricha

Cytotoxic sesquiterpene lactones and other constituents of centaurea omphalotricha

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Phytochemical research of the aerial parts of Centaurea omphalotricha led to the isolation of three new sesquiterpene lactones, 4'-acetyl cynaropicrin, 4'-acetyl cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven sesquiterpene lactones, two isoprenoids and three flavonoids. The structures of the new compounds were elucidated by means of extensive 1D and 2D NMR, and MS, and by comparison with reported data in the literature. The effect of sesquiterpene lactones on the viability of the human tumor cell lines HL-60 and U937 was also investigated and 3-acetyl cynaropicrin, and 4'-acetyl cynaropicrin were found to be the most cytotoxic compounds against human leukemia cells with an IC50 values of 2.0 ± 0.9 and 5.1 ± 0.4 μmol L-1, respectively.

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Bibliographic Details
Main Authors: Kolli, El Hadj, León, Francisco, Benayache, Fadila, Estévez, Sara, Quintana, José, Estévez, Francisco, Brouard, Ignacio, Bermejo, Jaime, Benayach, Samir
Other Authors: Ministerio de Ciencia e Innovación (España)
Format: artículo biblioteca
Published: Sociedade Brasileira de Química 2012-05
Subjects:Centaurea, Asteraceae, Sesquiterpene lactones, Cytotoxic activity, HL-60,
Online Access:http://hdl.handle.net/10261/199406
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100000780
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Summary:Phytochemical research of the aerial parts of Centaurea omphalotricha led to the isolation of three new sesquiterpene lactones, 4'-acetyl cynaropicrin, 4'-acetyl cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven sesquiterpene lactones, two isoprenoids and three flavonoids. The structures of the new compounds were elucidated by means of extensive 1D and 2D NMR, and MS, and by comparison with reported data in the literature. The effect of sesquiterpene lactones on the viability of the human tumor cell lines HL-60 and U937 was also investigated and 3-acetyl cynaropicrin, and 4'-acetyl cynaropicrin were found to be the most cytotoxic compounds against human leukemia cells with an IC50 values of 2.0 ± 0.9 and 5.1 ± 0.4 μmol L-1, respectively.

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