Preparation of modified peptides: Direct conversion of α-amino acids into β-amino aldehydes
A direct method for the transformation of α-amino acids into β-amino aldehydes was developed, and applied to the modification of the C-terminal residue of peptides. The method takes place in good yields and under mild conditions. The application of this methodology to the preparation of small peptides with γ-amino alcohol units, which are precursors of analogues of peptaibol antibiotics, is also described.
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Published: |
Royal Society of Chemistry (UK)
2012-04-20
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| Subjects: | Peptides, Direct conversion, α-amino acids, β-amino aldehydes, |
| Online Access: | http://hdl.handle.net/10261/199402 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 |
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| Summary: | A direct method for the transformation of α-amino acids into β-amino aldehydes was developed, and applied to the modification of the C-terminal residue of peptides. The method takes place in good yields and under mild conditions. The application of this methodology to the preparation of small peptides with γ-amino alcohol units, which are precursors of analogues of peptaibol antibiotics, is also described. |
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