Evidence of intraovarian follicular dominance effects during controlled ovarian stimulation in a sheep model
Objective To evaluate intraovarian dominance effects in a sheep model and to determine whether local factors, independent of FSH-mediated pathways, are capable of interfering with the final development of subordinate follicles. Design Observational, model study. Setting Public research unit. Animal(s) Three hundred sixty-four adult Manchega ewes. Intervention(s) Synchronization of estrous cycle with intravaginal progestogens and ovarian stimulation with FSH; ovarian ultrasonography, laparoscopies, and embryo recoveries. Main Outcome Measure(s) Determination of morphological characteristics and developmental competence of ovarian follicles. Result(s) The presence of a dominant follicle affects number and viability of embryos from the ipsilateral ovary in females that are treated with high FSH doses; this effect, modulated by season and phase of the estrous cycle, highlights the role of LH in follicular dominance. Conclusion(s): The current study confirms, in a sheep model, the existence of local effects from dominant follicles over neighboring follicles, by direct action and independently from systemic pathways through FSH modulation. © 2008 American Society for Reproductive Medicine.
| Main Authors: | , |
|---|---|
| Format: | journal article biblioteca |
| Language: | English |
| Published: |
Elsevier
2008
|
| Subjects: | Ovarian stimulation, Follicular status, Dominance, Embryo, Sheep, |
| Online Access: | http://hdl.handle.net/20.500.12792/1923 http://hdl.handle.net/10261/293799 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Objective To evaluate intraovarian dominance effects in a sheep model and to determine whether local factors, independent of FSH-mediated pathways, are capable of interfering with the final development of subordinate follicles. Design Observational, model study. Setting Public research unit. Animal(s) Three hundred sixty-four adult Manchega ewes. Intervention(s) Synchronization of estrous cycle with intravaginal progestogens and ovarian stimulation with FSH; ovarian ultrasonography, laparoscopies, and embryo recoveries. Main Outcome Measure(s) Determination of morphological characteristics and developmental competence of ovarian follicles. Result(s) The presence of a dominant follicle affects number and viability of embryos from the ipsilateral ovary in females that are treated with high FSH doses; this effect, modulated by season and phase of the estrous cycle, highlights the role of LH in follicular dominance. Conclusion(s): The current study confirms, in a sheep model, the existence of local effects from dominant follicles over neighboring follicles, by direct action and independently from systemic pathways through FSH modulation. © 2008 American Society for Reproductive Medicine. |
|---|