Establishment of a zebrafish infection model for the study of wild-type and recombinant European sheatfish virus
Amphibian-like ranaviruses include pathogens of fish, amphibians, and reptiles that have recently evolved from a fish-infecting ancestor. The molecular determinants of host range and virulence in this group are largely unknown, and currently fish infection models are lacking. We show that European sheatfish virus (ESV) can productively infect zebrafish, causing a lethal pathology, and describe a method for the generation of recombinant ESV, establishing a useful model for the study of fish ranavirus infections.
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| Main Authors: | , , , , , , , |
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| Format: | journal article biblioteca |
| Language: | English |
| Published: |
American Society for Microbiology
2015
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| Online Access: | http://hdl.handle.net/20.500.12792/2664 http://hdl.handle.net/10261/293662 |
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| Summary: | Amphibian-like ranaviruses include pathogens of fish, amphibians, and reptiles that have recently evolved from a fish-infecting ancestor. The molecular determinants of host range and virulence in this group are largely unknown, and currently fish infection models are lacking. We show that European sheatfish virus (ESV) can productively infect zebrafish, causing a lethal pathology, and describe a method for the generation of recombinant ESV, establishing a useful model for the study of fish ranavirus infections. |
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