Quasispecies dynamics and RNA virus extinction
The extinction of foot-and-mouth disease virus (FMDV) is strongly influenced by mutation rates, types of mutations, relative viral fitness and virus population regimens during infection. Here we review experimental results and theoretical models that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related FMDV clones subjected to serial bottleneck events. The results suggest procedures to master key parameters to develop effective antiviral strategies based on virus entry into error catastrophe. © 2004 Elsevier B.V. All rights reserved.
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| Main Authors: | , , , |
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| Format: | artículo de revisión biblioteca |
| Language: | English |
| Published: |
Elsevier
2005
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| Subjects: | Foot-and-mouth disease virus, 5-Fluorouracil, 5-Azacytidine, Mutation, |
| Online Access: | http://hdl.handle.net/20.500.12792/1115 http://hdl.handle.net/10261/289929 |
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| Summary: | The extinction of foot-and-mouth disease virus (FMDV) is strongly influenced by mutation rates, types of mutations, relative viral fitness and virus population regimens during infection. Here we review experimental results and theoretical models that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related FMDV clones subjected to serial bottleneck events. The results suggest procedures to master key parameters to develop effective antiviral strategies based on virus entry into error catastrophe. © 2004 Elsevier B.V. All rights reserved. |
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