LP-51: Determining of a broad range of organic chemicals in seminal plasma through an innovative LC-HRMS-based methodology suitable for target and non-target analysis
In recent years, there has been a growing concern about the impact of emerging pollutants on reproductive health and semen quality in healthy men. Most studies have focused on investigating the association between human semen quality and exposure to organic contaminants in blood or urine samples. However, there is a notable lack of effective methodologies for detecting a wide range of organic chemicals in semen. To address this gap, we have developed and validated a robust LC-HRMS methodology for semen analysis. This methodology is capable of determining over 2,000 chemicals in seminal plasma and is compatible with suspect and non-target strategies, making it valuable for studies on male fertility. To demonstrate the potential of this methodology in characterizing the chemical exposome in seminal plasma, we analyzed exogenous organic chemicals and associated metabolites, such as plastic additives, PFAS, flame retardants, surfactants, and insecticides, in ten samples obtained from the LED-FERTYL general population cohort based in Catalonia, Spain.
| Main Authors: | , , , , , , , , , , |
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| Format: | Comunicación de congreso biblioteca |
| Language: | English |
| Published: |
Elsevier
2023-09
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| Subjects: | LC-HRMS, Ensure healthy lives and promote well-being for all at all ages, |
| Online Access: | http://hdl.handle.net/10261/354129 |
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| Summary: | In recent years, there has been a growing concern about the impact of emerging pollutants on reproductive health and semen quality in healthy men. Most studies have focused on investigating the association between human semen quality and exposure to organic contaminants in blood or urine samples. However, there is a notable lack of effective methodologies for detecting a wide range of organic chemicals in semen. To address this gap, we have developed and validated a robust LC-HRMS methodology for semen analysis. This methodology is capable of determining over 2,000 chemicals in seminal plasma and is compatible with suspect and non-target strategies, making it valuable for studies on male fertility. To demonstrate the potential of this methodology in characterizing the chemical exposome in seminal plasma, we analyzed exogenous organic chemicals and associated metabolites, such as plastic additives, PFAS, flame retardants, surfactants, and insecticides, in ten samples obtained from the LED-FERTYL general population cohort based in Catalonia, Spain. |
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