Exploring the effects of phenolic compounds to reduce intestinal damage and improve the intestinal barrier integrity: A systematic review of in vivo animal studies
complications and disease such as sepsis and death, whereas, the role of food bioactive molecules (i. e. phenolic compounds (PCs) on the intestinal barrier, is still unknown. The current aim was to explore the benefits of the oral PC administration on the intestinal barrier integrity in animals. Methods: The effects of PCs on the intestinal barrier integrity in in vivo animal models of intestinal inflammation were assessed up-to August 2020 from the PubMed, SCOPUS, and Cochrane Library databases under the PRISMA methodology. The risk of bias was assessed from ARRAY and SCYRCLE tools. Results: From 1241 articles, 14 studies were included. In animals, oral resveratrol (n ¿ 6) improves the intestinal barrier integrity and reduces intestinal damage. Additionally, grape seed extract (n ¿ 2), curcumin (n ¿ 1), genistein (n ¿ 1), chlorogenic acid (n ¿ 1), grape pomace (n ¿ 1), olive leaf (n ¿ 1) or cranberry extract (n ¿ 1) improve the intestinal barrier integrity downregulating various inflammatory molecules (TNF-a, and other interleukins), and increasing the antioxidant enzymes in animals. Furthermore, resveratrol, quercetin, epigallocatechin, and other PCs improve the epithelial barrier integrity and pro-inflammatory molecule expression in the intestinal epithelia. Conclusions: The oral PC administration in animals improves the intestinal barrier integrity and function from three main mechanisms: 1) The reduction of pro-inflammatory molecules, 2) the improvement in tight-junction protein expression, and 3) the improvement of the antioxidant intracellular activity suggesting the potential use of PCs in the management of intestinal injury in humans, particularly for resveratrol, the most studied PC.
Main Authors: | , , , , , , |
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Other Authors: | |
Format: | artículo biblioteca |
Published: |
Elsevier
2021-04
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Subjects: | Intestinal, Barrier, Integrity, Microbiota, Phenolic compounds, Health, |
Online Access: | http://hdl.handle.net/10261/261956 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100008105 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100010198 http://dx.doi.org/10.13039/501100007512 http://dx.doi.org/10.13039/501100011033 |
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Summary: | complications and disease such as sepsis and death, whereas, the role of food bioactive molecules (i. e. phenolic compounds (PCs) on the intestinal barrier, is still unknown. The current aim was to explore the benefits of the oral PC administration on the intestinal barrier integrity in animals.
Methods: The effects of PCs on the intestinal barrier integrity in in vivo animal models of intestinal inflammation were assessed up-to August 2020 from the PubMed, SCOPUS, and Cochrane Library databases under the PRISMA methodology. The risk of bias was assessed from ARRAY and SCYRCLE tools.
Results: From 1241 articles, 14 studies were included. In animals, oral resveratrol (n ¿ 6) improves the intestinal barrier integrity and reduces intestinal damage. Additionally, grape seed extract (n ¿ 2), curcumin
(n ¿ 1), genistein (n ¿ 1), chlorogenic acid (n ¿ 1), grape pomace (n ¿ 1), olive leaf (n ¿ 1) or cranberry extract (n ¿ 1) improve the intestinal barrier integrity downregulating various inflammatory molecules (TNF-a, and other interleukins), and increasing the antioxidant enzymes in animals. Furthermore, resveratrol, quercetin, epigallocatechin, and other PCs improve the epithelial barrier integrity and pro-inflammatory molecule expression in the intestinal epithelia.
Conclusions: The oral PC administration in animals improves the intestinal barrier integrity and function from three main mechanisms: 1) The reduction of pro-inflammatory molecules, 2) the improvement in tight-junction protein expression, and 3) the improvement of the antioxidant intracellular activity suggesting the potential use of PCs in the management of intestinal injury in humans, particularly for resveratrol, the most studied PC. |
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