Genetic adaptation of the antibacterial human innate immunity network

[Background] Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions. The evolution of the immune system has therefore been influenced by these pressures. Genomic scans have revealed that immune system is one of the functions enriched with genes under adaptive selection.

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Bibliographic Details
Main Authors: Casals, Ferran, Sikora, Martin, Laayouni, Hafid, Montanucci, Ludovica, Muntasell, Aura, Lazarus, Ross, Calafell, Francesc, Awadalla, Philip, Netea, Mihai G., Bertranpetit, Jaume
Other Authors: Ministerio de Ciencia e Innovación (España)
Format: artículo biblioteca
Language:English
Published: BioMed Central 2011-07-11
Online Access:http://hdl.handle.net/10261/39453
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100002809
http://dx.doi.org/10.13039/100000002
http://dx.doi.org/10.13039/501100004587
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Summary:[Background] Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions. The evolution of the immune system has therefore been influenced by these pressures. Genomic scans have revealed that immune system is one of the functions enriched with genes under adaptive selection.