Antibacterial behavior of chitosan-sodium hyaluronate-PEGDE crosslinked films

Antibacterial behavior of chitosan-sodium hyaluronate-PEGDE crosslinked films

Chitosan is a natural polymer that can sustain not only osteoblast adhesion and proliferation for bone regeneration purposes, but it is also claimed to exhibit antibacterial properties towards several Gram-positive and Gram-negative bacteria. In this study, chitosan was modified with sodium hyaluronate, crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and both osteoblast cytotoxicity and antibacterial behavior studied. The presence of sodium hyaluronate and PEGDE on chitosan was detected by FTIR, XRD, and XPS. Chitosan (CHT) films with sodium hyaluronate crosslinked with PEGDE showed a better thermal stability than pristine hyaluronate. In addition, osteoblast cytocompatibility improved in films containing sodium hyaluronate. However, none of the films exhibit antimicrobial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus while exhibiting low to mild activity against Salmonella typhimurion.

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Bibliographic Details
Main Authors: Martha Gabriela Chuc-Gamboa, Carolina María Cámara Perera, Fernando Javier Aguilar-Ayala, ROSSANA FARIDE VARGAS CORONADO, JUAN VALERIO CAUICH RODRIGUEZ, DIANA MARIA ESCOBAR GARCIA, Luis Octavio Sanchez Vargas, Neith Pacheco López, Julio San Roman Del Barrio
Format: info:eu-repo/semantics/article biblioteca
Language:eng
Subjects:info:eu-repo/classification/Autores/CHITOSAN, info:eu-repo/classification/Autores/SODIUM HYALURONATE, info:eu-repo/classification/Autores/PEGDE, info:eu-repo/classification/Autores/ANTIBACTERIAL, info:eu-repo/classification/Autores/ESCHERICHIA COLI, info:eu-repo/classification/Autores/ENTEROCOCCUS FAECALIS, info:eu-repo/classification/Autores/STAPHYLOCOCCUS AUREUS, info:eu-repo/classification/Autores/SALMONELLA TYPHIMURION, info:eu-repo/classification/cti/7, info:eu-repo/classification/cti/33, info:eu-repo/classification/cti/3312, info:eu-repo/classification/cti/331208,
Online Access:http://cicy.repositorioinstitucional.mx/jspui/handle/1003/2138
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Summary:Chitosan is a natural polymer that can sustain not only osteoblast adhesion and proliferation for bone regeneration purposes, but it is also claimed to exhibit antibacterial properties towards several Gram-positive and Gram-negative bacteria. In this study, chitosan was modified with sodium hyaluronate, crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and both osteoblast cytotoxicity and antibacterial behavior studied. The presence of sodium hyaluronate and PEGDE on chitosan was detected by FTIR, XRD, and XPS. Chitosan (CHT) films with sodium hyaluronate crosslinked with PEGDE showed a better thermal stability than pristine hyaluronate. In addition, osteoblast cytocompatibility improved in films containing sodium hyaluronate. However, none of the films exhibit antimicrobial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus while exhibiting low to mild activity against Salmonella typhimurion.

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