Anti-inflammatory activity of critonia aromatisans and montanoa grandiflora leaves extracts, plants used in mayan traditional medicine to treat inflammation
The aim of the study is to investigate anti-inflammatory properties of polar and non-polar extracts prepared from Critonia aromatisans and Montanoa grandiflora, two common native species used in Mayan traditional ointments to treat inflammation, joint pain and rheumatism. The anti-inflammatory properties of methanol/acetonitrile and nhexane leaf extracts were tested in vivo and in vitro. The extracts of C. aromatisans and M. grandiflora decreased in a concentration-dependent manner lipopolysaccharide (LPS)-induced nitric oxide (NO) production without affecting the cell viability. the extracts of C. aromatisans at dose of 200 mg/kg exhibited substantial anti-inflammatory activity in the carrageenan-induced paw oedema test and 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema inhibition assay with a reduction in inflammation of up to 90 and 80%, respectively. These results validate the traditional uses by Mayan communities that endorse the use of this species to treat inflammation.
Main Authors: | , , , , , , , |
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Format: | info:eu-repo/semantics/article biblioteca |
Language: | eng |
Subjects: | info:eu-repo/classification/Autores/CRITONIA AROMATISANS, info:eu-repo/classification/Autores/MONTANOA GRANDIFLORA, info:eu-repo/classification/Autores/INFLAMMATION, info:eu-repo/classification/Autores/CARRAGEENAN, info:eu-repo/classification/Autores/NITRIC OXIDE, info:eu-repo/classification/Autores/MACROPHAGES, info:eu-repo/classification/cti/2, |
Online Access: | http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1498 |
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Summary: | The aim of the study is to investigate anti-inflammatory properties of polar and non-polar extracts prepared from Critonia aromatisans and Montanoa grandiflora, two common native species used in Mayan traditional ointments to treat inflammation, joint pain and rheumatism. The anti-inflammatory properties of methanol/acetonitrile and nhexane leaf extracts were tested in vivo and in vitro. The extracts of C. aromatisans and M. grandiflora decreased in a concentration-dependent manner lipopolysaccharide (LPS)-induced nitric oxide (NO) production without affecting the cell viability. the extracts of C. aromatisans at dose of 200 mg/kg exhibited substantial anti-inflammatory activity in the carrageenan-induced paw oedema test and 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema inhibition assay with a reduction in inflammation of up to 90 and 80%, respectively. These results validate the traditional uses by Mayan communities that endorse the use of this species to treat inflammation. |
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