Anti-inflammatory activity of critonia aromatisans and montanoa grandiflora leaves extracts, plants used in mayan traditional medicine to treat inflammation

The aim of the study is to investigate anti-inflammatory properties of polar and non-polar extracts prepared from Critonia aromatisans and Montanoa grandiflora, two common native species used in Mayan traditional ointments to treat inflammation, joint pain and rheumatism. The anti-inflammatory properties of methanol/acetonitrile and nhexane leaf extracts were tested in vivo and in vitro. The extracts of C. aromatisans and M. grandiflora decreased in a concentration-dependent manner lipopolysaccharide (LPS)-induced nitric oxide (NO) production without affecting the cell viability. the extracts of C. aromatisans at dose of 200 mg/kg exhibited substantial anti-inflammatory activity in the carrageenan-induced paw oedema test and 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema inhibition assay with a reduction in inflammation of up to 90 and 80%, respectively. These results validate the traditional uses by Mayan communities that endorse the use of this species to treat inflammation.

Bibliographic Details

Main Authors:	Fabiola Elizabeth Villa de la Torre, ANA MARIA PUEBLA PEREZ, VICTOR ERMILO ARANA ARGAEZ, ROLFFY RUBEN ORTIZ ANDRADE, GREGORIO DE JESUS CARBALLO UICAB, MARTHA ELENA MENDEZ GONZALEZ, MIRBELLA DEL ROSARIO CACERES FARFAN, ROCIO DE LOURDES BORGES ARGAEZ
Format:	info:eu-repo/semantics/article biblioteca
Language:	eng
Subjects:	info:eu-repo/classification/Autores/CRITONIA AROMATISANS, info:eu-repo/classification/Autores/MONTANOA GRANDIFLORA, info:eu-repo/classification/Autores/INFLAMMATION, info:eu-repo/classification/Autores/CARRAGEENAN, info:eu-repo/classification/Autores/NITRIC OXIDE, info:eu-repo/classification/Autores/MACROPHAGES, info:eu-repo/classification/cti/2,
Online Access:	http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1498
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