The advancements, challenges and future implications of the CRISPR/Cas9 system in swine research

Clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds, thus improving yields. Additionally, CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research. In this review, we present the advancements of the CRISPR/Cas9 system in swine research such as animal breeding, vaccine development, xenotransplantation, and disease modelling. We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies.

Bibliographic Details

Main Authors:	Zhang, J., Khazalwa, Emmanuel M., Abkallo, Hussein M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, Lucilla, Xie, S.
Format:	Journal Article biblioteca
Language:	English
Published:	Elsevier 2021-05
Subjects:	swine, research, genomics, crispr,
Online Access:	https://hdl.handle.net/10568/113738 https://doi.org/10.1016/j.jgg.2021.03.015
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