Polar Alkaloids from the Caribbean Marine Sponge Niphates digitalis
A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7- ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.
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| Main Authors: | , , , , |
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| Format: | Journal Contribution biblioteca |
| Language: | English |
| Published: |
2010
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| Subjects: | Cytotoxicity, Sponges, |
| Online Access: | http://hdl.handle.net/1834/3860 |
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| Summary: | A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic
polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the
major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7-
ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of
spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and
the first evidence of the presence of 1 from a natural source. |
|---|