Steroidal glycosides from the marine sponge Pandaros acanthifolium
The chemical composition of the Caribbean sponge Pandaros sp. was investigated and led to the isolation of seven new steroidal glycosides namely pandarosides A-D (1, 3, 4 and 6) along with the three methyl esters of pandarosides A, C, and D (2, 5 and 7). Their structures were characterized as 3β-[β-glucopyranosyl-(1→2)-β-glucopyranosyloxyuronic acid]-16-hydroxy- 5α,14β-poriferast-16-ene-15,23-dione (1) and its methyl ester (2), 3β-[β- glucopyranosyloxyuronic acid]-16-hydroxy-5α,14β-poriferast-16-ene-15,23-dione (3), 3β-[β- glucopyranosyl-(1→2)-β-glucopyranosyloxyuronic acid]-16-hydroxy-5α,14β-cholest-16-ene- 15,23-dione (4) and its methyl ester (5), 3β-(β-glucopyranosyloxyuronic acid)-16-hydroxy- 5α,14β-cholest-16-ene-15,23-dione (6) and its methyl ester (7) on the basis of detailed spectroscopic analyses, including 2D NMR and HRESI-MS studies. Pandarosides A-D and their methyl esters (1-7) are all characterized by a rare 2-hydroxycyclopentenone D-ring with a 14β configuration.
Main Authors: | , , , , , |
---|---|
Format: | Journal Contribution biblioteca |
Language: | English |
Published: |
2009
|
Subjects: | Sponges, |
Online Access: | http://hdl.handle.net/1834/3859 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The chemical composition of the Caribbean sponge Pandaros sp. was investigated and led to
the isolation of seven new steroidal glycosides namely pandarosides A-D (1, 3, 4 and 6) along
with the three methyl esters of pandarosides A, C, and D (2, 5 and 7). Their structures were
characterized as 3β-[β-glucopyranosyl-(1→2)-β-glucopyranosyloxyuronic acid]-16-hydroxy-
5α,14β-poriferast-16-ene-15,23-dione (1) and its methyl ester (2), 3β-[β-
glucopyranosyloxyuronic acid]-16-hydroxy-5α,14β-poriferast-16-ene-15,23-dione (3), 3β-[β-
glucopyranosyl-(1→2)-β-glucopyranosyloxyuronic acid]-16-hydroxy-5α,14β-cholest-16-ene-
15,23-dione (4) and its methyl ester (5), 3β-(β-glucopyranosyloxyuronic acid)-16-hydroxy-
5α,14β-cholest-16-ene-15,23-dione (6) and its methyl ester (7) on the basis of detailed
spectroscopic analyses, including 2D NMR and HRESI-MS studies. Pandarosides A-D and
their methyl esters (1-7) are all characterized by a rare 2-hydroxycyclopentenone D-ring with a 14β configuration. |
---|