Genome-wide association study on long-yearling scrotal circumference in Canchim cattle.

Genome-wide association study on long-yearling scrotal circumference in Canchim cattle.

Genome-wide association studies provide valuable information for understanding the genetic control of complex traits in livestock. The goal of this study was to investigate the association of the BovineHD BeadChip SNP genotypes with estimated breeding values for long-yearling scrotal circumference adjusted to 420 days (SC420) in Canchim beef cattle. A total 435 SNPs were significantly associated with SC420 (10% chromosome-wise FDR), of which 30 were located in genes on chromosomes 5, 13, and 14, including HEY1, PLCG1, PAG1, ZFHX4, PEX2, FABP5, FABP12, MED30, and TRHR genes. These genes play a role in biological processes related to reproduction, fat deposition, and hormonal systems development. Future studies targeting these regions and genes could provide better understanding of the genetic architecture of reproduction traits in Canchim cattle.

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Bibliographic Details
Main Authors: BUZANSKAS, M. E., GROSSI, D. A., VENTURA, R. V., CHUD, T. C. S., URBINATI, I., MEIRELLES, S. L. C., MOKRY, F. B., SCHENKEL, F. S., REGITANO, L. C. de A., MUNARI, D. P.
Other Authors: LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Format: Separatas biblioteca
Language:pt_BR
por
Published: 2014-08-29
Subjects:Candidate gene, Canchim breed., animal breeding.,
Online Access:http://www.alice.cnptia.embrapa.br/alice/handle/doc/993744
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Summary:Genome-wide association studies provide valuable information for understanding the genetic control of complex traits in livestock. The goal of this study was to investigate the association of the BovineHD BeadChip SNP genotypes with estimated breeding values for long-yearling scrotal circumference adjusted to 420 days (SC420) in Canchim beef cattle. A total 435 SNPs were significantly associated with SC420 (10% chromosome-wise FDR), of which 30 were located in genes on chromosomes 5, 13, and 14, including HEY1, PLCG1, PAG1, ZFHX4, PEX2, FABP5, FABP12, MED30, and TRHR genes. These genes play a role in biological processes related to reproduction, fat deposition, and hormonal systems development. Future studies targeting these regions and genes could provide better understanding of the genetic architecture of reproduction traits in Canchim cattle.

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