Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.

Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.

Currently available leishmaniasis treatments are limited due to severe side effects. Arrabidaea chica is a medicinal plant used in Brazil against several diseases. In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A. chica against Leishmania amazonensis and L. infantum, as well as on the interaction of these parasites with host cells. Promastigotes were treated with several concentrations of the fractions obtained from A. chica for determination of their minimum inhibitory concentration (MIC).

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Bibliographic Details
Main Authors: RODRIGUES, I. A., AZEVEDO, M. M. B., CHAVES, F. C. M., ALVINO, C. S., ALVIANO, D. S., VERMELHO, A. B.
Other Authors: Igor A. Rodrigues, Universidade Federal do Rio de Janeiro; Mariana M. B. Azevedo, Programa de Pós-Graduação Ciências dos Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro; FRANCISCO CELIO MAIA CHAVES, CPAA; Celuta S. Alviano, Universidade Federal do Rio de Janeiro; Daniela S. Alviano, Universidade Federal do Rio de Janeiro; Alane B. Vermelho, Universidade Federal do Rio de Janeiro.
Format: Separatas biblioteca
Language:English
eng
Published: 2014-04-10
Subjects:Arrabidaea chica, Crajiru,
Online Access:http://www.alice.cnptia.embrapa.br/alice/handle/doc/984315
http://dx.doi.org/10.1155/2014/985171
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Summary:Currently available leishmaniasis treatments are limited due to severe side effects. Arrabidaea chica is a medicinal plant used in Brazil against several diseases. In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A. chica against Leishmania amazonensis and L. infantum, as well as on the interaction of these parasites with host cells. Promastigotes were treated with several concentrations of the fractions obtained from A. chica for determination of their minimum inhibitory concentration (MIC).

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